Eureka moment for TCR mimics

In the race to access the wealth of intracellular molecular targets once considered undruggable, Eureka Therapeutics Inc. is pioneering TCR-like antibodies that capitalize on the ability of TCRs to recognize tumor antigens. But the company will need to satisfy concerns about off-target binding that sank earlier TCR-based therapies against the same class of antigens.

Last month, Eureka and its partners at Memorial Sloan Kettering Cancer Center published a study in the Journal of Clinical Investigation demonstrating that its TCR-mimicking (TCRm) antibodies can recognize and kill cancer cells expressing the intracellular PRAME tumor antigen in mice...