Group identifies method for retinal neuron regeneration

In a paper published in Nature, researchers at the University of Washington identified an approach for generating new inner retinal neurons that could be used to treat visual impairment caused by retinal diseases.

In a mouse model of NMDA-induced retinal damage, the team showed that overexpression of proneural transcripton factor achaete-scute complex homolog 1 (ASCL1; MASH1) plus an intravitreal injection of an histone deacetylase (HDAC) inhibitor used to increase chromatin accessibility promoted neural differentiation and proliferation of Müller glia...