NIH researchers identify genes essential for immunotherapy

In a paper published in Nature, researchers at NIH's NCI and colleagues identified about 100 genes that may be tied to immunotherapy resistance in cancer cells.

The researchers used a CRISPR-Cas9 (CRISPR-associated protein 9) loss-of-function screen in human melanoma cell lines targeting over 19,000 protein-encoding genes to test the impact of somatic mutations on T cell response. The authors sought to identify genes that have key roles in antigen presentation and interferon-gamma signaling, which affects T cell recognition of tumors...