ARTICLE | Translation in Brief
Neutrophil bias
How modulation of neutrophils by IL-27 could treat stroke
October 18, 2017 11:38 PM UTC
Researchers from the University of Texas Health Science Center have found that IL-27 promotes an anti-inflammatory phenotype in neutrophils that can treat stroke in mice. But safety issues around the recombinant cytokine have the team looking downstream of IL-27 instead, to drug iron metabolism regulators released by the cells.
Neutrophils are important cellular mediators of inflammation recruited into the brain during stroke, where they can adopt pro- or anti-inflammatory phenotypes that exacerbate or ameliorate stroke, respectively. ...
BCIQ Company Profiles