ARTICLE | Translation in Brief
A notch for tankyrase
NYU paper identifies new cancer opportunities for tankyrase inhibitors
January 18, 2018 11:05 PM UTC
New York University School of Medicine researchers have identified a multitude of tankyrase targets, including factors in the Notch and Wnt/β-catenin pathways, that offer new opportunities for tankyrase inhibitors in cancer.
In a Nature Communications study last month, the NYU team conducted proteomic screens in HEK cells with single- and double-knockout of tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS; TNKS1) and TNKS2, and identified 74 targets whose activities were regulated by interaction with one or both enzymes...