ARTICLE | Product Development
AA Viral meme
James Wilson’s findings on AAV toxicity should have limited impact on the vectors’ use in humans
February 2, 2018 10:30 PM UTC
Gene therapy pioneer James Wilson’s revelation of two new types of toxicity in animals receiving high systemic doses of adeno-associated viral vectors is unlikely to herald a major disruption of the AAV space, though it remains to be seen whether they influenced his decision to resign as SAB chair of Solid Biosciences Inc.
Wilson plus five AAV researchers who spoke with BioCentury concurred that any repercussions likely would be limited to a handful of products given at high systemic doses to treat neurological or musculoskeletal disorders in children. ...