Stem cell-based vaccine could give broad immunity against cancers

A Stanford University team published a paper in Cell Stem Cell showing a stem cell-based vaccine prevented tumor growth and reactivated the immune system in several cancer models. The therapy could grant broad immunity against multiple cancers or act as an adjunctive immunotherapy to circumvent the tumor microenvironment's immunosuppressive effects.

Using RNA sequencing, the researchers found an overlap in gene expression profiles between human and mouse induced pluripotent stem cells (iPSCs) and cancer cells, suggesting iPSCs could expose the immune system to tumor antigens...