ARTICLE | Translation in Brief
JAKs and clots
Brigham and Women’s team suggest JAK-2 inhibitors could treat thrombosis
June 6, 2018 4:32 PM UTC
Brigham and Women’s Hospital researchers have uncovered the mechanisms behind a major complication in bone marrow disorders by linking a JAK-2 mutation with thrombosis in patients and mice, and identified a way to treat blood clotting by inhibiting JAK-2.
The Science Translational Medicine study connected a known Janus kinase-2 (JAK-2) mutation found in patients with myeloproliferative neoplasms (MPNs) to thrombosis caused by increased formation of neutrophil extracellular traps (NETs) -- a component of innate immunity -- and suggested JAK inhibition could extend beyond patients with MPN to treat thrombosis...