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ARTICLE | Preclinical News

Inhibiting MMP2 reverses leptin resistance associated with obesity

Sandi Wong
August 22, 2018 11:03 PM UTC

University of California San Diego researchers and colleagues showed that inhibiting cleavage of leptin receptor (LEPR; CD295) by matrix metalloproteinase 2 (MMP2) could help prevent leptin resistance and treat obesity.

Obesity is associated with high circulating concentrations of leptin, a hormone that signals satiety to the brain, but reduced LEPR signaling (known as leptin resistance). However, the molecular mechanisms leading to leptin resistance have not been fully characterized...

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