ARTICLE | Clinical News
Bifunctional agonist could treat pain, opioid dependency
September 7, 2018 4:45 PM UTC
A team from Astraea Therapeutics LLC (Mountain View, Calif.) and Wake Forest Baptist Medical Center developed a bifunctional agonist targeting two opioid receptors that could treat pain without opioid-related side effects and reverse opioid dependency.
Opioids that target the mu opioid receptor (MOR; OPRM1), including morphine, oxycodone and hydrocodone, are effective at providing pain relief but can lead to misuse, addiction and overdose...