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BioCentury
ARTICLE | Distillery Therapeutics

Neurology

Chris Lieu
September 26, 2018 5:39 PM UTC

Cell culture and mouse studies suggest inhibiting Rho kinase could help to treat AD. In primary rat cortical neurons stimulated with DKK1 to produce β amyloid, the Rho kinase inhibitor Eril fasudil increased dendritic spine numbers and decreased β amyloid levels compared with no treatment. In a mouse model of AD, Eril decreased levels of β amyloid and plaque area in the cortex and hippocampus compared with vehicle. Next steps could include testing Rho kinase inhibition in additional models of AD...

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