Two strategies block immune-mediated metastases in mice

Cold Spring Harbor Laboratory researchers and a team from two Italian institutions have published two different strategies to fight immune-mediated lung metastases.

Dormant cancer cells can persist for years before awakening and proliferating, leading to metastasis. In two studies published this week, the researchers suggest mechanisms by which the immune system triggers metastasis, through either neutrophil extracellular traps (NETs) released by neutrophils or an immunosuppressive environment that can be controlled through alteration of the lung microbiome...