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ARTICLE | Clinical News

Gilead looks towards NASH combo data after selonsertib fails in second Phase III

April 25, 2019 10:44 PM UTC

Gilead's selonsertib has failed in another Phase III NASH trial, this time missing the primary endpoint in patients with a less severe stage of fibrosis. The company will focus on its combination strategy to treat non-alcoholic steatohepatitis (NASH).

Gilead Sciences Inc. (NASDAQ:GILD) said Thursday that selonsertib (GS-4997) missed the primary endpoint of at least a one-stage histologic improvement in fibrosis without worsening of NASH at 48 weeks vs. placebo in the Phase III STELLAR-3 trial to treat patients with bridging fibrosis (F3) due to NASH. In February, the company said selonsertib missed the same primary endpoint in the Phase III STELLAR-4 trial in compensated cirrhosis (F4) due to NASH, which is a more severe form of fibrosis than F3 (see "Gilead’s selonsertib fails Phase III for NASH compensated cirrhosis"). ...

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