Inhibition of BACH1 or the genes it controls for metastatic lung cancer

INDICATION: Lung cancer

Inhibiting the pro-metastatic transcription factor BACH1 or its gene targets MCT1, HMOX1, HK2 and GADPH could treat metastatic lung cancer. In patients with metastasized lung cancer, levels of BACH1 and HMOX1 protein were higher in lung metastases than in primary tumors. Additionally, higher BACH1 levels were associated with lymph node metastasis, higher disease stage and shorter survival. In human lung cancer cells, an shRNA against BACH1, the MCT1 inhibitor AZD3965 or tool compound inhibitors of HMOX1, HK2 or GADPH, decreased cell migration. In mice with the disease, the shRNA against BACH1, AZD3965 or tool compound inhibitors of HMOX1 and GADPH decreased the number of metastases...