Important: New Login Process

We've updated our access and security system. The first time you log in, enter your work email, and we'll guide you through the process.

  • If your organization uses Single Sign-On (SSO), you will be redirected to your company's login portal.
  • If you log in with a username and password, you will be prompted to set a new password before accessing your account.

Go to the Login Page to get started.

We appreciate your cooperation during this transition. If you need assistance, please call +1 650-552-4224 or email support@biocentury.com.

BioCentury

Inhibiting the EIF4G1-EIF4E interaction to treat autism

Claire Quang
December 19, 2019 9:59 PM UTC

INDICATION: Autism

Disrupting the EIF4G1-EIF4E interaction could treat autism, a disorder characterized by social deficits and associated with increased dendritic spine densities and mutations in the E3 ligase complex component CUL3. In a CUL3-deficient mouse model of autism, a tool compound inhibitor of the EIF4G1-EIF4E interaction reduced social deficits and dendritic spine density. Next steps include testing the EIF4G1-EIF4E inhibitor in other models of autism...

Get Unlimited Access
Continue reading with a free trial.
Start a Free TrialLog In
Or Purchase This Article

BCIQ Company Profiles

Case Western Reserve University