BioCentury
ARTICLE | Product Development

Coronavirus biology: where products in clinical testing intervene

An overview of how therapies in clinical trials for coronavirus interfere with viral biology

February 8, 2020 3:13 AM UTC
Updated on Mar 26, 2020 at 1:31 AM UTC

The 13 therapies in clinical trials to treat coronavirus map to at least half a dozen mechanisms, intervening at three different steps in the viral cycle or manipulating different aspects of the host immune response.

As of Feb. 7, 13 clinical trials to treat 2019-nCoV acute respiratory disease have been registered on ClinicalTrials.gov, and another 19 have been listed on the Chinese Clinical Trial Register. The count excludes traditional Chinese medicines and intravenous immunoglobulin therapies not known to come from individuals who recovered from 2019-nCoV infection (see “Clinical Trials for Coronavirus Have Begun”)...