Previewing CD47 efficacy data at SITC & ASH: Data Byte

Abstracts at SITC and ASH are providing more data points on the efficacy of CD47 inhibitors, and the evidence suggests the target may hold promise in solid as well as liquid tumors.

Known as a “don’t eat me” signal, CD47 is a cell surface protein upregulated by tumor cells to avoid phagocytosis by macrophages. As companies developing anti-CD47 mAbs overcome the initial safety challenges of on-target, off-tumor toxicity, they are adding to the evidence base for the efficacy of this closely watched class of myeloid checkpoint inhibitors...