Distillery Therapeutics


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<h1 class="text title distillery_title" doc-editable="text" data-component-id="doc-1ef7l992d0">SIRT5 overexpression could rescue mitochondrial disease induced by SUCLA2 mutations</h1><div class="byline ng-tns-c17-4 ng-star-inserted" data-component-id="doc-1ef7l9he70">
    <span class="ng-tns-c17-4" doc-editable="text">By Claire Quang, Staff Writer</span>
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

Gladstone Institutes

University of California San Francisco

University of Helsinki

Buck Institute for Research on Aging

DISEASE CATEGORY: Endocrine/metabolicINDICATION: Mitochondrial disease......

Endocrine/Metabolic

Mitochondrial disease

Succinate-CoA ligase ADP-forming beta subunit (SUCLA2)

Sirtuin 5 (SIRT5)

SIRT5 overexpression could rescue mitochondrial disease induced by SUCLA2 mutations

DISEASE CATEGORY: Endocrine/metabolic<br/>INDICATION: Mitochondrial disease Promoting the expression of the desuccinylase SIRT5 could treat a hereditary mitochondrial encephalomyopathy caused by

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