DATA GRAPHICS | Product Development
IRAK4 inhibitor pipeline: Data Byte
January 5, 2021 1:58 AM UTC
Several inflammatory and cancer indications will soon see human proof-of-concept data from small molecules targeting the kinase IRAK4, as a class of at least eight such molecules makes its way through early-stage trials.
IRAK4 mediates innate immune signaling from its position at the intersection between interleukin (IL)-1 family receptors and toll-like receptors (TLRs). The kinase acts upstream of other IRAK family members and of several cytokines and chemokines in the inflammatory cascade. ...