Distillery Therapeutics


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<h1 class="text title distillery_title" doc-editable="text" data-component-id="doc-1ef7l992d0">Modulating RNA splicing through RBM39 and PRMT inhibition to induce tumor neoantigen expression</h1><div class="byline ng-tns-c17-4 ng-star-inserted" data-component-id="doc-1ef7l9he70">
    <span class="ng-tns-c17-4" doc-editable="text">By Claire Quang, Staff Writer</span>
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

Fred Hutchinson Cancer Research Center

Memorial Sloan Kettering Cancer Center

DISEASE CATEGORY: CancerINDICATION: Colorectal cancer; melanoma......

Cancer

Colorectal cancer

Melanoma

Protein arginine methyltransferase 1 (PRMT1)

Modulating RNA splicing through RBM39 and PRMT inhibition to induce tumor neoantigen expression

DISEASE CATEGORY: Cancer<br/>INDICATION: Colorectal cancer; melanoma Inhibiting the accessory splicing factor RBM39 or PRMT enzymes, which modify RNA splicing factors, could treat cancer by promoting

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