The largest A rounds of 2021 

Last year saw at least 10 therapeutics developers raise series A rounds of $100 million or more, with three crossing the $200 million mark. Those numbers parallel 2020, which also had 10 companies raise $100 million-plus A rounds, with two breaking $200 million. 

The single-biggest series A financing of 2021 was a $250 million mega-round raised by U.K.-based Centessa Pharmaceuticals plc (NASDAQ:CNTA). The biopharma went on to raise $379.5 million in an IPO a few months later, marking one of the biggest NASDAQ IPOs of 2021. Centessa, a Medicxi portfolio company, brings together 10 asset-centric plays across a variety of therapeutic areas including autoimmune, nephrology, hematology and oncology under one umbrella...