Neoantigen-reactive T cell signatures; plus CAR T cell therapy improvements and more

Three teams used single-cell RNA sequencing methods to identify signatures of tumor-specific T cells and published the results in Cancer Cell.

A group led by Eric Tran at Providence Cancer Institute sequenced tumor-infiltrating lymphocytes (TILs) from bile duct and pancreatic cancer patients. They found that neoantigen-reactive exhausted CD8⁺ T cells had high CXCL13 and GZMA expression and exhausted CD4⁺ T cells had high HOPX or GPR56 and lacked CD127 expression...