BioCentury
ARTICLE | Product Development

Lilly’s tirzepatide set to compete with Novo in obesity after hitting in Phase III

GIP/GLP-1 agonist hits target of 20% absolute weight reduction

April 28, 2022 2:18 PM UTC

Lilly’s tirzepatide appears set to challenge Novo for market share in obesity after new Phase III data showed higher doses of the dual agonist provided nearly 20% placebo-adjusted weight reduction.

Eli Lilly and Co. (NYSE:LLY) reported 72-week data from the Phase III SURMOUNT-1 trial that showed the 10 mg and 15 mg doses of tirzepatide achieved 19.5% and 20.9% weight reduction, compared with 3.1% for placebo. The figures are based on treatment-regiment estimand, a statistical method that calculates efficacy regardless of treatment discontinuation...