ARTICLE | Discovery & Translation
Shifting from binary markers to whole-genome signatures in cancer
Classifying tumors by mutational patterns across the whole genome could enable more predictive patient stratification and drug matching
May 27, 2022 12:15 AM UTC
An algorithm built on Genomics England’s data troves is bringing tumor mutational signatures closer to replacing a gene-by-gene view of patient stratification.
The approach, published in Science by a University of Cambridge team, relies on growing access to whole-genome sequencing (WGS), which at about $600 is becoming comparable to standard-of-care approaches like CT scans, said principal investigator Serena Nik-Zainal. “I think there will be a paradigm shift, moving toward having the complete profile.”...