Stem cell transplants aim for next level of sophistication

Pairing CAR T cell therapies with stem cell transplants could overcome key challenges of both treatments, with a little help from gene editing.

At least seven abstracts presented at this year’s American Society of Hematology (ASH) conference described gene edits to stem cell transplants that protected the cells from cancer immunotherapies —including CAR T cells — that would otherwise be toxic to the bone marrow compartment. ...