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BioCentury
ARTICLE | Discovery & Translation

CRISPR knockdown tech from Doudna lab; plus CAR Ts for myasthenia gravis and more

BioCentury’s roundup of translational news

January 28, 2023 12:07 AM UTC

Jennifer Doudna’s lab described in Nature Biotechnology an RNA-guided CRISPR technology to degrade target RNAs with high efficiency and minimal off-target effects.

The  University of California Berkeley team showed CRISPR–Csm, a multi-protein complex that is part of type III CRISPR immune systems in prokaryotes, lacks the off-target cleavage of cellular RNAs characteristic of Cas13, and single-vector delivery of the Streptococcus thermophilus Csm complex induced 90-99% target RNA knockdown in human cells. The University of California has filed a patent on the use of the Csm system for eukaryotic RNA knockdown...

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