Single-cell T cell atlas identifies new subsets; plus CoRegen’s cell therapy and more

University of Texas MD Anderson Cancer Center scientists and collaborators reported a single-cell atlas of T cells from 308,048 transcriptomes across 16 cancer types and identified a unique stress response state, dubbed T_STR, characterized by heat shock gene expression. The authors found upregulated heat shock gene expression in intratumoral CD4/CD8⁺ cells from patients whose tumors had not responded to immune checkpoint inhibitor treatment, indicating a potential role of T_STR cells in resistance to immunotherapy.

“Our well-annotated T cell reference maps, web portal and automatic alignment/annotation tool could provide valuable resources for T cell therapy optimization and biomarker discovery,” said the authors of the Nature Medicine paper...