ARTICLE | Discovery & Translation
A circular RNA-encoded GBM target, ORM2 for NASH and more
New targets and compounds from BioCentury’s Distillery
August 8, 2023 1:06 AM UTC
Innovations captured last week in BioCentury’s Distillery, a curated database of translational academic research from over 25 journals, included new targets for cancer, NASH, Alzheimer’s and radioactivity poisoning, plus an antiparasitic small molecule.
Inhibition of MET404, a MET variant encoded by m6A-modified circular RNA that induces constitutively active MET signaling, could help treat glioblastoma (GBM) by decreasing GBM stem cell self-renewal, invasiveness and tumorigenicity. ...