Boosting lymphatic drainage for TBI recovery; improved CASTs and more

University of Rochester researchers, including CNS2 Inc. co-founder Steven Goldman, showed in Nature that pan-adrenergic receptor inhibition reduced brain edema and improved functional recovery in a mouse model of traumatic brain injury (TBI). 

Treatment with a cocktail of ADRA1 antagonist prazosin, ADRA2 antagonist atipamezole, and propranolol, a broad ADRB antagonist, after TBI boosted the lymphatic export of fluid, macromolecular proteins and cellular debris, and led to reduced neuroinflammation, tau accumulation and cognitive loss. CNS2 has licensed relevant patents...