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Radiopharmaceuticals could soon get their first blockbuster

Pluvicto’s steep launch appears on track to surpass $1B in sales this year

March 21, 2024 12:34 AM UTC

Precious few targeted radiopharmaceuticals have reached the commercial market, but the future looks bright for the treatment modality as companies big and small place big bets on next-generation technologies. This year, the therapeutic class appears set to get its first blockbuster drug, assuming the launch of Novartis’ Pluvicto continues its steep rise.

Novartis AG (SIX:NOVN; NYSE:NVS), an early mover in radiopharmaceuticals, completed its $3.9 billion takeout of Advanced Accelerator Applications S.A. in January 2018, the same month FDA approved the biotech’s Lutathera 177Lu-Dotatate to treat somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NET). The European Commission approved the radiotherapy in 2017. Since then, Lutathera has brought in $2.6 billion in sales. ...