Action Required: Password Reset on Next Login

As part of our recent security and system improvements, a password reset will be required the next time you log in. This applies to username/password users only; SSO users are not affected.

To reset your password, please visit the Reset Password page.

We appreciate your patience during this transition and are available to assist with any questions. For support, please call us at +1 650-552-4224 or email us at support@biocentury.com.

BioCentury
ARTICLE | Discovery & Translation

Science Spotlight: Engineered CD47 protects CAR T cells from macrophages and more

BioCentury’s roundup of translational innovations

June 6, 2024 12:09 AM UTC

A team led by serial entrepreneur and  Stanford University professor Crystal Mackall revealed a method to increase the antitumor efficacy of anti-CD47 mAbs for solid tumors.

Blocking of the CD47-SIRPA pathway, by which cancers send a ‘don’t eat me’ signal to the immune system, can lead to increased macrophage-mediated phagocytosis of tumor cells, but has led to limited efficacy in the clinic. To further increase tumor cell killing, the Nature paper authors combined an anti-CD47 mAb with tumor-targeted CAR T cells. The strategy was stymied, however, by rapid macrophage-mediated clearance of the CAR Ts...

Get Unlimited Access
Continue reading with a free trial.
Or Purchase This Article