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BioCentury
ARTICLE | Discovery & Translation

Science Spotlight: Obesity, GLP-1R influence immune checkpoints; and more

BioCentury’s roundup of translational innovations

June 21, 2024 4:52 PM UTC

Separate papers have suggested that obesity and GLP-1R activity influence immunity, hinting that GLP-1R could be an avenue for preventing transplant rejection and treating cancer. 

In the first study, a team at the University of Milan showed that GLP-1R may act as an immune checkpoint on T cells to directly inhibit CD8+ T cell immune response. ...

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