Science Spotlight: Targeted protein relocalization, rejuvenating aged eggs, and more

Stanford University researchers described a method in Nature to relocalize endogenous proteins within subcellular compartments.

The team identified a group of shuttle proteins that can be co-opted using a bifunctional molecule, dubbed targeted relocalization-activating molecules (TRAMs), to re-localize a target protein. The authors then showed it could use nuclear hormone receptors as shuttles to redistribute disease-driving mutant proteins from the cytoplasm to the nucleus...