ARTICLE | Discovery & Translation
Science Spotlight: Macrophage-fibroblast cross-talk in heart failure
BioCentury’s roundup of translational innovations also includes synthetic gene regulators, three longevity genes and more
October 31, 2024 11:53 PM UTC
In back-to-back Nature papers, independent groups revealed that intervening in macrophage-fibroblast cross-talk could reduce cardiac fibrosis. Both groups found that IL-1β signaling from specific macrophage populations activates fibroblasts, and reinforced the role of the fibroblast transcription factor MEOX1 as a key regulator of heart failure.
Amgen Inc. (NASDAQ:AMGN) and collaborators at Washington University School of Medicine in St. Louis identified a disease-associated fibroblast trajectory using multi-omic data from 45 healthy donor, acutely infarcted and chronically failing human hearts...