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ARTICLE | Product Development

Alzheimer’s roundup: Clinical progress and setbacks at CTAD

Readouts showcase promise of Roche’s brainshuttle; plus mixed results from Lilly, Lexeo and Anavex

November 6, 2024 10:54 PM UTC

The latest data from Roche’s Phase Ib/IIa study of trontinemab suggest the pharma’s brainshuttle technology is doing its job. 

The brainshuttle-enabled anti-amyloid mAb, concentrates in the CNS via active transport, appears on track to achieve the goal of accelerating β-amyloid plaque clearance and simultaneously decreasing the drug class’ most troublesome safety risks, brain swelling and hemorrhage...

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