ARTICLE | Discovery & Translation
Science Spotlight: snoRNA control of protein secretion, plus dual agonists for obesity
BioCentury’s roundup of translational innovations also includes an Arkuda-J&J granulin gene therapy
December 13, 2024 2:10 AM UTC
Serial entrepreneur Chuan He and colleagues from University of Chicago developed a method to detect cellular RNA targets of non-coding small nucleolar RNAs (snoRNAs), and uncovered a snoRNA-based mechanism that controls protein secretion that could be tapped for therapeutic and biomanufacturing applications.
snoRNAs are typically known for guiding RNA modifications, but the authors of the Cell paper found that many snoRNA-mRNA interactions occur outside of snoRNA-guided RNA modification sites, suggesting non-canonical functions...
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