Letter from the Editor: Untangling reality and expectations in 2025 

Optimism appears to be in short supply entering 2025, replaced largely by exhaustion. So what are the options for making 2025 over-deliver on expectations?

For sure, you don’t have to be a Polyanna to agree there are plenty of signals of meaningful progress in drug development. However, there are still areas where progress has taken longer than it should, and others where it just hasn’t happened at all. And you don’t have to be a Grinch to acknowledge there are also real concerns and threats to the sector’s continued progress...