Expressionedits: Multifold improvement in protein production
University of Cambridge spinout enhances gene expression by adding in multiple short non-coding regions
Methods to drive up protein expression could support translational research, solve manufacturing bottlenecks for protein therapeutics, and improve gene therapy efficiency to allow for lower doses and improved safety. That’s what Expressionedits aims to accomplish through a platform that optimizes introns in therapeutic transgenes.
Cambridge, U.K.-based Expressionedits Ltd. is adding short introns into transgenes to more closely mimic the natural genetic architecture found in highly expressed human genes. Its AI/ML platform predicts which introns to use, where to insert them and how many to include in a gene to maximize therapeutic protein production and improve the effectiveness of gene therapies...