BioCentury
ARTICLE | Discovery & Translation

Science Spotlight: Targets to enhance CAR-NK cell therapies

BioCentury’s roundup of translational innovations also includes Recode’s multi-organ targeted LNPs and tau-vulnerable neurons in Alzheimer’s

June 24, 2025 10:57 PM UTC

Two recent papers describe intracellular checkpoints that limit NK cell antitumor activity, suggesting targets to enhance the efficacy of CAR-NK cell therapies.

One group, led by Katayoun Rezvani at the University of Texas MD Anderson Cancer Center, discovered that the cAMP-responsive transcription factor CREM acts as a brake on CAR-NK cell activation and persistence...

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