Targeting P2Y14 for liver fibrosis

Inhibiting the damage-associated molecular pattern (DAMP) receptor P2Y14 could help treat liver fibrosis. In primary mouse liver cells, transcriptomic screening to identify DAMPs that mediate the pro-fibrotic effects of dying hepatocytes on hepatic stellate cells, followed by a ligand-receptor interaction analysis that combined proteomic and single-cell RNA sequencing data, identified the interaction between P2Y14 in hepatic stellate cells and its ligands UDP-glucose and UDP-galactose, which are released by dying hepatocytes, as drivers of stellate cell activation and liver fibrosis. ...