Targeting CYLD to promote neuron survival in Parkinson's

Inhibiting the deubiquitinase CYLD could help treat Parkinson's disease. In three Drosophila models of Parkinson's, an shRNA knockdown screen of deubiquitinating enzymes showed knockdown of CYLD decreased climbing defects compared with a control shRNA, and cell-based and biochemical assays showed CYLD knockdown increased neuron viability, mitochondrial biogenesis and degradation of the transcriptional repressor PARIS. ...