CNOT6L inhibitor for metabolic disease

An inhibitor of the deadenylase CNOT6L could help treat diet-induced metabolic syndrome by increasing expression of GDF15 and FGF21, hepatokines that decrease food intake and increase energy expenditure. In silico and high-throughput screening of small molecule libraries identified a compound that inhibited CNOT6L with an IC50 of 14.12 μM, and surface plasmon resonance confirmed the compound bound the CNOT6L catalytic domain with a Kd of 7.6 μM. ...