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ARTICLE | Distillery Therapeutics

A spike- and nucleoprotein-targeting mRNA vaccine for SARS-CoV-2

BC Staff
December 7, 2022 8:41 PM UTC

An mRNA vaccine encoding the SARS-CoV-2 N nucleocapsid protein and the SARS-CoV-2 S spike protein could protect against a wide range of variants, including Delta and Omicron.

In mice, vaccination with a nucleoside-modified mRNA construct encoding the full-length SARS-CoV-2 N protein from the ancestral SARS-CoV-2 strain and delivered via lipid nanoparticles increased SARS-CoV-2 N-specific CD4+ and CD8+ T cell activation in the spleen and IgG levels in the serum compared with vehicle...

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