Important: New Login Process

We've updated our access and security system. The first time you log in, enter your work email, and we'll guide you through the process.

  • If your organization uses Single Sign-On (SSO), you will be redirected to your company's login portal.
  • If you log in with a username and password, you will be prompted to set a new password before accessing your account.

Go to the Login Page to get started.

We appreciate your cooperation during this transition. If you need assistance, please call +1 650-552-4224 or email support@biocentury.com.

BioCentury
ARTICLE | Distillery Therapeutics

A spike- and nucleoprotein-targeting mRNA vaccine for SARS-CoV-2

December 7, 2022 8:41 PM UTC

An mRNA vaccine encoding the SARS-CoV-2 N nucleocapsid protein and the SARS-CoV-2 S spike protein could protect against a wide range of variants, including Delta and Omicron.

In mice, vaccination with a nucleoside-modified mRNA construct encoding the full-length SARS-CoV-2 N protein from the ancestral SARS-CoV-2 strain and delivered via lipid nanoparticles increased SARS-CoV-2 N-specific CD4+ and CD8+ T cell activation in the spleen and IgG levels in the serum compared with vehicle...

Get Unlimited Access
Continue reading with a free trial.
Or Purchase This Article