Engineered Tregs expressing an inflammation-sensing receptor for GvHD

Tregs expressing artificial immune receptors that activate cells in response to inflammatory signals could help treat GvHD and other inflammatory conditions.

Mouse and human Tregs were engineered to express an artificial immune receptor that fused the extracellular and transmembrane domains of the TNF family receptor LTBR to intracellular domains of CD28 and CD3ζ, and co-culture with cell lines expressing an LTBR ligand induced activation of these engineered Tregs, but not Tregs expressing an irrelevant chimeric antigen receptor (CAR)...