cGAS-activating nanoassemblies for solid tumors

Nanoassemblies that release manganese ions and a topoisomerase inhibitor into the tumor microenvironment could help treat solid tumors by activating cGAS-STING signaling in dendritic cells and cancer cells.

The nanoassemblies consisted of albumin proteins modified with dendritic cell-targeting mannose groups and carrying manganese ions that enhance cGAS activity, cross-linked with tumor-targeting ferritin nanocages delivering a topoisomerase inhibitor tool compound that induces immunogenic cell death and release of cGAS-activating double-stranded DNA; the complex dissociates into monodispersive units in the acidic tumor microenvironment...