Inhibiting endothelin A receptor for acute kidney injury sequelae

Inhibiting endothelin A receptor after acute kidney injury could help prevent progression to chronic kidney disease and the associated risk of cardiovascular disease.

Plasma and urine levels of the endothelin A receptor ligand EDN1 were higher in samples from acute kidney injury patients than healthy controls, and kidney tissue levels of mRNA encoding EDN1 and endothelin A were higher in acute kidney injury patients than in controls without kidney injury. ...