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ARTICLE | Distillery Therapeutics

A multivalent vaccine for New World arenaviruses

March 8, 2023 6:48 PM UTC

A multivalent vaccine expressing New World arenavirus (NWA) glycoprotein epitopes could help protect against existing and emerging strains.

The pentavalent vaccine was generated by expressing glycoprotein epitopes from all five pathogenic NWAs known in South America – Machupo, Guanarito, Chapare, Sabiá and Junin viruses – in a single live hyperattenuated Mopeia virus vector, creating a vaccine that induced cross-reactive neutralizing antibodies against all five antigens in cynomolgus monkeys...

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