An anti-citrullinated protein mAb with therapeutic effects in RA
An autoantibody that forms an immune complex on macrophage surfaces by binding citrullinated ENO1 and engaging FCGR2B via its Fc receptor could help treat RA by promoting anti-inflammatory macrophage polarization.
In a mouse model of collagen antibody-induced RA, the mAb decreased arthritis scores and improved histology compared with a control antibody...
BCIQ Company Profiles