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ARTICLE | Distillery Therapeutics

An anti-citrullinated protein mAb with therapeutic effects in RA

March 8, 2023 6:55 PM UTC

An autoantibody that forms an immune complex on macrophage surfaces by binding citrullinated ENO1 and engaging FCGR2B via its Fc receptor could help treat RA by promoting anti-inflammatory macrophage polarization.

In a mouse model of collagen antibody-induced RA, the mAb decreased arthritis scores and improved histology compared with a control antibody...

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