A universal vaccine antigen for SARS-CoV-2

A SARS-CoV-2 spike protein vaccine designed based on phylogenetic analysis of thousands of viral sequences could help protect against COVID-19 by inducing broadly neutralizing antibodies that neutralize a wide range of variants.

An analysis of 2,675 SARS-CoV-2 S protein sequences collected in a public database before the Delta variant emerged identified high-frequency residues that reflect cross-clade generality in sequence evolution, which were incorporated into a protein subunit vaccine that was combined with adjuvants...