Blocking LBP suppression of monoamine synthesis for depression

Blocking the inhibitory interaction between the innate immune regulator LBP and the monoamine synthesis enzymes DBH and DDC could help treat depression by relieving monoamine insufficiency.

In serum from patients with non-psychotic major depression and psychotic major depression, DBH and DDC activity was lower than in serum from healthy individuals. Co-immunoprecipitation and mass spectrometry experiments in human serum identified LBP as a DBH-binding protein, and LBP expression was higher in the sera of patients with major depression than healthy individuals...